Pharmacology and the Nursing Process by Linda Lane Lilley: Practice Exam

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Dipyridamole is combined with which other drug to enhance antiplatelet activity?

  1. Warfarin

  2. Clopidogrel

  3. Aspirin

  4. Eptifibatide

The correct answer is: Aspirin

Dipyridamole is combined with aspirin to enhance antiplatelet activity because aspirin is a nonsteroidal anti-inflammatory drug (NSAID) that acts as an inhibitor of prostaglandin synthesis by inhibiting the enzyme cyclooxygenase (COX). Aspirin's antiplatelet effects are due to its ability to inhibit thromboxane A2 production. On the other hand, warfarin, clopidogrel, and eptifibatide are anticoagulant drugs that work differently from aspirin and would not be used in combination to enhance antiplatelet activity. Warfarin interferes with the synthesis of vitamin K-dependent clotting factors, clopidogrel inhibits ADP-induced platelet aggregation, and eptifibatide blocks the glycoprotein IIb/IIIa receptor on platelets, reducing their ability

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