Pharmacology and the Nursing Process by Linda Lane Lilley: Practice Exam

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What kind of drugs might enhance clearance of corticosteroids, requiring careful management?

Phenytoin, phenobarbital, and rifampin
Antivirals and antibiotics
Antifungals and antimalarials
Calcium channel blockers and diuretics

The correct answer is: Phenytoin, phenobarbital, and rifampin

Explanation A: Phenytoin, phenobarbital, and rifampin may interfere with the metabolism of corticosteroids, enhancing their clearance and reducing their effectiveness. This requires careful management to adjust the dosage of corticosteroids. B, C, and D are incorrect because they do not have an effect on corticosteroid levels. Antivirals, antibiotics, antifungals, antimalarials, calcium channel blockers, and diuretics do not alter the metabolism of corticosteroids.