Pharmacology and the Nursing Process by Linda Lane Lilley: Practice Exam

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Which drug interaction does NOT result in increased serum levels of xanthine derivatives?

  1. Allopurinol

  2. Rifampin

  3. Cimetidine

  4. Quinolones

The correct answer is: Rifampin

Allopurinol is a drug used to treat gout and can increase serum levels of xanthine derivatives. Cimetidine is a medication that treats heartburn and excess stomach acid, and can also increase xanthine levels. Quinolones are antibacterial drugs that can affect xanthine levels. However, Rifampin is a drug used to treat tuberculosis and it does NOT interact with xanthine, so it is the correct answer. This is because Rifampin works by inducing the liver enzymes that break down xanthine, resulting in a decrease in serum levels of xanthine derivatives.

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