Pharmacology and the Nursing Process by Linda Lane Lilley: Practice Exam

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Which drug interaction is NOT a concern with Clopidogrel (Plavix)?

  1. Calcium channel blockers

  2. Amiodarone

  3. Antifungal medications

  4. Proton pump inhibitors

The correct answer is: Antifungal medications

Clopidogrel is a drug used to prevent blood clots and is primarily metabolized by enzymes in the liver. This means that drugs that inhibit these enzymes can significantly affect the effectiveness of Clopidogrel. Options A, B and D are all examples of medications that can interact with Clopidogrel because they can inhibit these liver enzymes, making Clopidogrel less effective and potentially increasing the risk of blood clots. Option C, antifungal medications, do not typically interact with Clopidogrel as they do not affect these liver enzymes. Therefore, this option is not a concern when taking Clopidogrel.

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