Pharmacology and the Nursing Process by Linda Lane Lilley: Practice Exam

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Which genetic factors are helpful in determining the initial dosage of Warfarin?

  1. ABO and Rh

  2. CYP2CP and VKORC1

  3. Hemoglobin S

  4. MC1R

The correct answer is: CYP2CP and VKORC1

While ABO and Rh are blood type genes and Hemoglobin S is linked to sickle cell anemia, none of these genes have been found to have a significant impact on determining the initial dosage of Warfarin. MC1R is a gene that is associated with red hair and skin cancer, but it also does not have a role in determining Warfarin dosage. On the other hand, CYP2CP and VKORC1 are both genes that play a crucial role in metabolizing and regulating the response to Warfarin, making them the correct answer.

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